To this end, we employ both genetic (like leptin-receptor knockouts) and diet-induced (high sugar, high fat or western diets) models to induce metabolic syndrome as well as alcohol-binging models and we characterize the specific response of mice deficient in proteins involved in the metabolism of fructose (fructokinase and aldolase b). Furthermore, our lab has demonstrated that besides its dietary source, fructose can be produced in the body and that the metabolism of this endogenous fructose is an important deleterious step in the pathogenesis of kidney disease, both in acute kidney injury (as it would occur with radiocontrast agents or dehydration) and chronic kidney disease (as in diabetic kidney disease).

In particular, our research has discovered that the metabolism of dietary sugar (as in sodas), and specifically, fructose is directly linked to metabolic dysfunction, oxidative stress and inflammation and is also responsible for craving and the hedonic pleasure associated with sugar and alcohol intake. Our lab is focused on identifying potential mechanisms that we can target to prevent or even treat multiple features associated with this condition (obesity, diabetes, fatty liver, dyslipidemia or high blood pressure) as well as with alcoholism and alcoholic liver disease. These results suggest that hedonic evaluation may have an important role in mate choice and showcase how mechanistic analysis can help understand evolutionary processes.Dietary sugar has been recognized both by basic research and epidemiological studies as an important player in the current epidemics of obesity and metabolic syndrome.

Further, females in the two species showed flips in approach/evasion of stimuli with comparable signal structure. Other topics include contingent valuation, hedonic pricing method, shadow prices, econometrics of contingent valuation, cost-effectiveness analysis. We use the two-stage Rosen approach employing data from multi-markets for the same wines to identify supply functions. Female treefrog responses ranged from approach to evasion, and the presence of an aversive stimulus tainted evaluation of an attractive stimulus. Two solutions have been proposed to tackle hedonic decline: including strongly emotional scenes to arouse viewers (peak oriented. This paper recognizes that the original Rosen (1974) hedonic theoretic framework excludes producer specific variables from the hedonic price function and justifies their inclusion only for second-stage attribute supply estimation. We tested the hypothesis of positive-to-negative behavioural responses in mate choice with a playback experiment using two treefrog species with ‘mirror image’ structures in their advertisement and aggressive calls. Further, change in preferred mate types can occur simply by changes (flips) in the evaluation of similar display features, adding to the dynamism of sexual selection as well as its strength.

Selection due to mate choice may therefore be stronger than currently appreciated. A Daubert Hearing on Hedonic Damage Testimony - Lawyers & Judges Publishing. This may contribute to the power of sexual selection because evaluations may range from positive to negative rather than simply from positive to neutral. Perpetual Calendar and Future Date Calculator - Lawyers & Judges Publishing. In such cases, the selective environment may be hedonic or affective in nature, as it consists of the evaluations of the individuals making the decisions. Sexual competition hinges on the ability to impress other conspecifics, to drive them away or attract them.

Hedonic calendar